Dinh/Dinh 2015/NOTES/2016-2-15: Difference between revisions

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==Twin MZ Analysis==
 
===(1) make methylation matrices & perform smoothing with bsseq===
* Methylation sites: minimum 4 samples with 3x depth of coverage per site.
* Smoothing parameters: number of sites (ns = 70), window size (h=1000)
===(2) Computing the T-statistics===
* Bsseq doesn't allow for paired samples T-test.
* Calculate the T-statistics and then perform segmentation to obtain DMRs
===(3) Visualize DMRs===
* Hclustering
*

Latest revision as of 01:45, 19 February 2016