AlanFung:Lab Notebook/DNA Methylation: Difference between revisions

From ZhangLabWiki
Jump to navigation Jump to search
>Alan6017518
(New page: '''DNA Methylation''' *Where 5 position of the pyrimidine ring of cytosines in the context of the dinucleotide sequence CpG *How *Response to stimuli diet toxins *Aberrant DNA methyla...)
 
>Alan6017518
No edit summary
Line 1: Line 1:
'''DNA Methylation'''
'''DNA Methylation'''
*What is DNA Methylation
It is the only genetically programmed DNA modification in mammals


*Where
*Where
5 position of the pyrimidine ring of cytosines in the context of the dinucleotide sequence CpG
Almost exclusively found on the 5 position of the pyrimidine ring of cytosines in the context of the dinucleotide sequence CpG
 
*Frequency
The majority (75%) of CpG dinucleotides throughout mammalian genomes are methylated


*How
*How
Line 22: Line 27:
Used to detect cancer at very early stages
Used to detect cancer at very early stages
  *Classify tumors
  *Classify tumors
*predict and monitor the response to antineoplastic treatment
*

Revision as of 21:17, 2 April 2009

DNA Methylation

  • What is DNA Methylation

It is the only genetically programmed DNA modification in mammals

  • Where

Almost exclusively found on the 5 position of the pyrimidine ring of cytosines in the context of the dinucleotide sequence CpG

  • Frequency

The majority (75%) of CpG dinucleotides throughout mammalian genomes are methylated

  • How
  • Response to stimuli

diet toxins

  • Aberrant DNA methylation

Leads to cancer - where genome wide hypomethylation coincides with gene-specific hypermethylation


  • Usage

The epigenetic mechanisms controlling and modulating gene expression through chromatin structure Closely interacts with histone modifications and chromatin-remodeling complexes to form the genomic chromatin landscape Essential for proper mammalian development Crucial for imprinting Plays a role in maintaining genomic stability and dosage compensation Used to detect cancer at very early stages

*Classify tumors
*predict and monitor the response to antineoplastic treatment 
*