AlanFung:Lab Notebook/DNA Methylation: Difference between revisions
>Alan6017518 (New page: '''DNA Methylation''' *Where 5 position of the pyrimidine ring of cytosines in the context of the dinucleotide sequence CpG *How *Response to stimuli diet toxins *Aberrant DNA methyla...) |
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'''DNA Methylation''' | '''DNA Methylation''' | ||
*What is DNA Methylation | |||
It is the only genetically programmed DNA modification in mammals | |||
*Where | *Where | ||
5 position of the pyrimidine ring of cytosines in the context of the dinucleotide sequence CpG | Almost exclusively found on the 5 position of the pyrimidine ring of cytosines in the context of the dinucleotide sequence CpG | ||
*Frequency | |||
The majority (75%) of CpG dinucleotides throughout mammalian genomes are methylated | |||
*How | *How | ||
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Used to detect cancer at very early stages | Used to detect cancer at very early stages | ||
*Classify tumors | *Classify tumors | ||
*predict and monitor the response to antineoplastic treatment | |||
* |
Revision as of 21:17, 2 April 2009
DNA Methylation
- What is DNA Methylation
It is the only genetically programmed DNA modification in mammals
- Where
Almost exclusively found on the 5 position of the pyrimidine ring of cytosines in the context of the dinucleotide sequence CpG
- Frequency
The majority (75%) of CpG dinucleotides throughout mammalian genomes are methylated
- How
- Response to stimuli
diet toxins
- Aberrant DNA methylation
Leads to cancer - where genome wide hypomethylation coincides with gene-specific hypermethylation
- Usage
The epigenetic mechanisms controlling and modulating gene expression through chromatin structure Closely interacts with histone modifications and chromatin-remodeling complexes to form the genomic chromatin landscape Essential for proper mammalian development Crucial for imprinting Plays a role in maintaining genomic stability and dosage compensation Used to detect cancer at very early stages
*Classify tumors *predict and monitor the response to antineoplastic treatment *