Ns126:Calendar/NOTES/2015-7-12: Difference between revisions

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>Shicheng
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File:WGBS.Phase2.Cluster.Revised.3.jpeg|Figure 1A. Hierarchical clustering based on WGBS revealed the relationships between hESC, N37 normals, Salk normals and cancers
File:WGBS.Phase2.Cluster.Revised.3.jpeg|Figure 1A. Hierarchical clustering based on WGBS revealed the relationships between hESC, N37 normals, Salk normals and cancers
*consider: batch differences in read depth, read length or other artifacts.
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Revision as of 17:13, 13 July 2015

Materials and Method

Dr. Zhang update the MONOD methylation haplotype result and therefore I can check the latest result in the relationship between samples and check the distinguish ability of cancer and normals based on methylation haplotype load.

Result

Relationship between samples in the propestive of hierarchical clustering based on MHL

Relationship between samples in the propestive of PCA analysis based on MHL

File:WGBS.MONOD.PCA.2.jpeg

Functional enrichment of the loci that have the highest loading to PC1 and PC2

Methylation 450K sample with CD, ESC and Cancer sample in the sapce of PC1 and PC2