Ns126:Calendar/NOTES/2015-6-26

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Revision as of 22:40, 26 June 2015 by >Shicheng (→‎Result)
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Methylation Block in HM450 microarray

Motivation

Dr.Zhang tried defined methylation haplotype and methylation blocks with GWBS data. and we are sure that these regions must have special biological, genomic or evolution functions. Therefore, I want to do the similar analysis in HM450K array. I will compare the regions identified in HM450 with the regions disovered by Dr. Zhang. In our hypothesis, the regions in my analysis would be a sutset of Dr. Zhang's regions.

Materials and Method

I collected pair-wised samples of 11 cancers from TCGA project.

Method

Materials and Dataset

TCGA Dataset

PBMC dataset

Result

High density CpG regions in 450K array

Correlation of high density CpG regions in 450K array

  • high correction region based on methylation 450K dataset


It is very interesting result: 1) cancer have two peak 2) cancer have more higher correction regions