Dinh/Dinh 2015/NOTES/2016-2-15
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Twin MZ Analysis
(1) make methylation matrices & perform smoothing with bsseq
- Smoothing parameters: number of sites (ns = 70), window size (h=1000)
(2) Computing the T-statistics
- Bsseq doesn't allow for paired samples T-test.
- Calculate the T-statistics and then perform segmentation to obtain DMRs
(3) Visualize DMRs
- Hclustering