Dinh/Dinh 2015/NOTES/2016-2-15

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Twin MZ Analysis

(1) make methylation matrices & perform smoothing with bsseq

  • Smoothing parameters: number of sites (ns = 70), window size (h=1000)

(2) Computing the T-statistics

  • Bsseq doesn't allow for paired samples T-test.
  • Calculate the T-statistics and then perform segmentation to obtain DMRs

(3) Visualize DMRs

  • Hclustering