AlanFung:Lab Notebook/DNA Methylation

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Revision as of 17:29, 2 April 2009 by >Alan6017518 (New page: '''DNA Methylation''' *Where 5 position of the pyrimidine ring of cytosines in the context of the dinucleotide sequence CpG *How *Response to stimuli diet toxins *Aberrant DNA methyla...)
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DNA Methylation

  • Where

5 position of the pyrimidine ring of cytosines in the context of the dinucleotide sequence CpG

  • How
  • Response to stimuli

diet toxins

  • Aberrant DNA methylation

Leads to cancer - where genome wide hypomethylation coincides with gene-specific hypermethylation


  • Usage

The epigenetic mechanisms controlling and modulating gene expression through chromatin structure Closely interacts with histone modifications and chromatin-remodeling complexes to form the genomic chromatin landscape Essential for proper mammalian development Crucial for imprinting Plays a role in maintaining genomic stability and dosage compensation Used to detect cancer at very early stages

*Classify tumors