Ylaine/2009-7-20
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Reading[edit]
Hoberman et al. "A probabilistic approach for SNP discovery in high-throughput human resequencing data"
- Developed SNP calling algorithm that improves accuracy of calling heterozygote SNPs
- Data is 454 sequencing (longer reads than Solexa)
- Random forest approach to classification based on variety of local and read-scale parameters
- Re-aligns unmapped reads using multiple sequence alignment
- Estimates PDF of fraction of reads resulting from a second allele that has been less preferentially amplified