CIRM BBAIII execution plan.
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Year 1[edit]
- iPSC reprogramming.
- Somatic cell types: Fibroblasts (PGP1F, BJ, IMR90), others??
- Reprogramming methods: 4F, 4F plus POLR1C shRNA, episomal??
- hESC/hiPSC differentiation.
- H1 (need to obtain the cell line through MTA), Hues3, HUES8.
- Exome sequencing and mutation validation.
- Existing lines (what??) versus new lines.
- Gene knock-in/knock-down experiments.
- What genes??
- Build a database??